The late-onset form of Pompe disease (LOPD) differs from the infantile-onset (IOPD) form in symptom onset and severity, as well as in rate of progression. Symptoms usually present in adulthood (early teens to anywhere from the second to sixth decades of life) but can occur as early as childhood (>1 year of age to pre-teen) and may vary from patient to patient. Timely and accurate diagnosis is important so appropriate disease management can be initiated promptly. Visit Clinical Presentation and Diagnosis to read more about the signs and symptoms of LOPD and its diagnosis.
The impact of a chronic, progressive disease like LOPD on the patient and their family is enormous. To read about the burden and progression of LOPD, visit Impact of LOPD. Management of late-onset Pompe disease requires coordinated care by a multidisciplinary team to optimize clinical outcomes. To learn more about management options, coordinating a care plan, and scheduling assessments, visit Managing LOPD.